The Potential of Exome Sequencing of Paired Colorectal Tumors and Synchronous Liver Metastases to Improve Treatment

Tweetable abstract

Sequencing exomes of synchronous and metachronous liver metastases of colorectal cancer has potential to enhance treatment, since they can have molecular profiles distinct from primary tumors.

Keywords::

• colorectal cancer
• exome
• KRAS
• liver metastasis
• metachronous
• next-generation sequencing
• personalized therapy
• prognosis
• progression
• synchronous

Financial & competing interests disclosure

This work was supported by the Czech Health Research Council grant no. NV19-08–00113 to P Souček, the Czech Science Foundation grant no. 23–05609S to V Hlaváč and the National Institute for Cancer Research – NICR (Programme EXCELES, ID project no. LX22NPO5102) – funded by the European Union – Next Generation EU. Funders played no role in study design, data collection, analysis and interpretation of data or the writing of this text. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by the Czech Health Research Council grant no. NV19-08–00113 to P Souček, the Czech Science Foundation grant no. 23–05609S to V Hlaváč and the National Institute for Cancer Research – NICR (Programme EXCELES, ID project no. LX22NPO5102) – funded by the European Union – Next Generation EU. Funders played no role in study design, data collection, analysis and interpretation of data or the writing of this text. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.