ABCB6, ABCB1 and ABCG1 Genetic Polymorphisms and Antidepressant Response of SSRIs in Chinese Depressive Patients

Abstract

Aim: Major depressive disorder is a common psychiatric disorder with worldwide prevalence. The most widely prescribed antidepressants are selective serotonin reuptake inhibitors (SSRIs). ATP-binding cassette proteins are responsible for the membrane transport of various molecules including antidepressive drugs. We investigated whether SNPs in ABCB6, ABCB1 and ABCG1 were associated with the treatment response of SSRIs. Materials & methods: A pharmacogenetic study genotyping nine SNPs was conducted in 290 major depressive disorder patients in the Chinese Han population. Allele and genotype frequencies were compared between responders and nonresponders. Results: The allele frequencies of rs28401781 and rs4148739 in ABCB1 showed significant difference between responders and nonresponders before correction (p = 0.0297 and p = 0.0359, respectively). No significant associations were detected for the ABCB6 or ABCG1 gene. Conclusion: Our results suggest that ABCB1 polymorphisms might be associated with SSRIs treatment response in the Chinese Han population.

Original submitted 29 April 2013; Revision submitted 29 July 2013

KEYWORDS::

• ABCB1
• ABCB6
• ABCG1
• major depressive disorder
• pharmacogenetics
• SSRIs

Acknowledgements

The authors appreciate the contribution of the members participating in this study, as well as the psychiatrists who helped us with the diagnosis.

Financial & competing interests disclosure

This work was supported by the 973 Program (2010CB529600), the National Key Technology R&D Program (2012BAI01B09 and 2009CB825606), the National Nature Science Foundation of China (81121001 and 31171237), the Shanghai Municipal Commission of Science and Technology Program 09DJ1400601 and the Shanghai Leading Academic Discipline Project (B205). This work was also supported by the National Hi-Tech Research and Development Program of China (grants 2004BA720A21-01 and 2009BAI77B06). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This work was supported by the 973 Program (2010CB529600), the National Key Technology R&D Program (2012BAI01B09 and 2009CB825606), the National Nature Science Foundation of China (81121001 and 31171237), the Shanghai Municipal Commission of Science and Technology Program 09DJ1400601 and the Shanghai Leading Academic Discipline Project (B205). This work was also supported by the National Hi-Tech Research and Development Program of China (grants 2004BA720A21-01 and 2009BAI77B06). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.