Abstract
The term steroid-dependent nephrotic syndrome refers to a specific pattern of disease whereby relapses of nephrosis occur while on, or soon after stopping, steroids. While children remain responsive to steroids, they are expected to retain renal function and eventually grow out of the condition. Until that happens, the aim of treatment is to prevent relapses while minimizing the toxic effects of the medications used. Steroids remain the mainstay therapy, but children with steroid-dependent nephrotic syndrome can become exposed to large doses and the aim is then to use so-called ‘steroidsparing’ strategies. This review discusses some of the more recent information available to help guide clinicians through this somewhat murky area of pediatric nephrology.
Financial & competing interests disclosure
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript