IL-27 Genetic Variation and Susceptibility of Dilated Cardiomyopathy in Chinese Han Population

Abstract

Aim: Accumulating data showed that IL-27 polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between two single nucleotide polymorphisms (SNPs) of IL-27 gene and dilated cardiomyopathy (DCM). Materials & methods: Two SNPs (rs153109 and rs17855750) of IL-27 gene were genotyped by PCR-restriction fragment length polymorphism in 261 DCM patients and 303 unrelated healthy subjects in Chinese Han population. Results: Compared with controls, our results showed that SNP rs153109 displayed significant associations with DCM in Chinese Han population, whereas no differences in genotype or allele frequencies were found between DCM patients and controls at SNP rs17855750. Conclusion: Our study showed that, for the first time, the association of the IL-27 gene SNP with the patients with DCM.

Keywords::

• cytokine
• dilated cardiomyopathy
• IL-12
• IL-27
• inflammation
• single nucleotide polymorphisms

Acknowledgements

This work was supported by the Applied Basic Research Programs of Science and Technology Commission Foundation of Sichuan Province (no. 2015JY0186), Scientific Research Foundation for the Returned Overseas Chinese Scholars of Sichuan Province (No. 2016064) and the National Natural Science Foundation of China for Young Scholar (no. 81600259).

Financial & competing interests disclosure

Y Chen receives funding from the Scientific Research Foundation for the Returned Overseas Chinese Scholars of Sichuan Province (no. 2016064), and the National Natural Science Foundation of China for Young Scholar (no. 81600259). H Wei receives funding from Science and Technology Commission Foundation of Sichuan Province (no. 2015JY0186). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

Y Chen receives funding from the Scientific Research Foundation for the Returned Overseas Chinese Scholars of Sichuan Province (no. 2016064), and the National Natural Science Foundation of China for Young Scholar (no. 81600259). H Wei receives funding from Science and Technology Commission Foundation of Sichuan Province (no. 2015JY0186). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.