Effect of Magnesium Sulfate on Morphine Activity Retention to Control Pain After Herniorrhaphy

Abstract

Aim: This research was carried out to compare magnesium sulfate (MgSO₄) with isotonic saline in terms of pain control after herniorrhaphy. Patients & methods: A randomized double-blind study, in which the patients were blind to all. A total of 100 patients who were candidates of herniorrhaphy were randomized into two groups: experimental and control (50 patients in each). Anesthesia was induced with 20% of 4 cc of morphine. The experimental and control group received postoperative 20% of 2 cc MgSO₄ in 2 cc of isotonic saline and 4 cc of isotonic saline, respectively. Result: The administration of postoperative morphine in control group 0.79 ± 1.48 mg was significantly higher to the experimental group 0.17 ± 0.63 mg during the first 24 h (p = 0.01). Conclusion: MgSO₄ increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.

KEYWORDS:

• herniorrhaphy
• magnesium sulfate
• morphine
• pain

Acknowledgements

The authors thank Department of Anesthesiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.