Expression Profile of the Immune Response Factors in Patients with Bronchial Asthma

ABSTRACT

Bronchial asthma is the most common chronic disease in infancy worldwide. Genetics factors play important part in the pathogenesis of bronchial asthma. The aim of the present study is by the method of quantitative PCR in real time to establish changes in gene expression, related to the immune response in patients with bronchial asthma and healthy controls. Changes in the pointed genes cause changes in the expression of various inflammatory proteins. Analysis of gene expression, which is at the basis of functional genomics, gives much more precious information on the effect of gene changes on the course of the disease. At comparison of gene expression in the separate clinical groups was found that the greater part of the 84 studied genes, were with increased expression.

Keywords:

• astma
• RT-PCR
• gene expression