Abstract
A double blind randomized trial was made to ascertain the effect of tranexamic acid (AMCA) (Cyklo-kapron®) on the postoperative blood loss after conization. The case material consisted of 50 women referred to the clinic because of dysplasia or non-invasive cancer of the cervix. Five patients were excluded for various reasons. The treatment started in the evening of the day of operation and was continued for another 12 days, the dose being three tablets every 8 hours, corresponding to 4.5 g of tranexamic acid daily when the active drug was given. During the first 7 postoperative days, when the patients were in hospital, the blood losses were determined quantitatively. Prophylactic treatment with tranexamic acid reduced the postoperative blood loss as compared with the placebo group, the blood losses being 23 ± 3.2 ml and 79 ± 20.4 ml respectively. Sudden profuse bleeding postoperatively, requiring remedial measures, occurred in 7 patients, all in the placebo group. With the exception of 1 patient in the placebo group, who complained of nausea, no side effects were recorded.