Abstract
In toxaemia, hepatosis, placental insufficiency, and other complications of pregnancy, fibrin deposits occur in the kidney, liver and placenta. When broken down these products appear in the blood as fibrin degradation products (F.D.P.). The value of repeated immunochemical determinations of F.D.P. was investigated in the serum of 705 pregnant women. F.D.P. in concentrations of 5 to 40 μg/ml were found in 78% patients who later developed clinical complications, particularly toxaemia and hepatosis. Further, a rapid latex-agglutination-inhibition test was evaluated. At concentrations of F.D.P. above 15 μg/ml complete agreement was found between the results of this test and those of the immunochemical method.