Abstract
The present investigation was performed to study the urodynamic effects of hormones on the lower urinary tract in women. Twenty-four stress incontinent and 6 continent women were randomly given E2 and E3 orally in doses of 4–8 mg per day for 3 weeks. Another group of 8 women were given a single i.m. injection of 1000 mg gestagen.
All the women were examined with simultaneous urethro-cystometry, including urethral pressure profile measurement, before and after treatment. After estrogen treatment the transmission of intraabdominal pressure to the urethra increased. Furthermore, there was a significant increase in maximum urethral pressure and urethral length at rest. After gestagen treatment no significant changes of the recorded parameters were observed.