In situ characterization of the inflammatory cell infiltrates of hyperplastic denture stomatitis

Anne Christine Johannessen Department of Oral Pathology and Forensic Odontology, University of Bergen, Bergen, Norway; Departments of Stomatognathic Physiology, Oral Pathology and Prosthodontics, Karolinska Institutet, Stockholm, Sweden

GÖRan Isacsson Department of Oral Pathology and Forensic Odontology, University of Bergen, Bergen, Norway; Departments of Stomatognathic Physiology, Oral Pathology and Prosthodontics, Karolinska Institutet, Stockholm, Sweden

Rune Nilsen Department of Oral Pathology and Forensic Odontology, University of Bergen, Bergen, Norway; Departments of Stomatognathic Physiology, Oral Pathology and Prosthodontics, Karolinska Institutet, Stockholm, Sweden

Tom Bergendal Department of Oral Pathology and Forensic Odontology, University of Bergen, Bergen, Norway; Departments of Stomatognathic Physiology, Oral Pathology and Prosthodontics, Karolinska Institutet, Stockholm, Sweden

Abstract

Cryostat sections from 14 surgical specimens were examined to determine whether selected factors of the immune response related to histopathological reactions are present in the palatal mucosa affected by hyperplastic denture stomatitis. By means of various immunological techniques the presence of IgG, IgA, IgM, complement factor C3c, receptors for the Fc region of IgG (FcR) and for complement factor C3b (C3bR), T lymphocytes, and macrophages were studied. The inflammatory infiltrate was mainly located in the papillary part of the lamina propria. IgG, IgA, and IgM appeared both in plasma cells and intercellularly. FcR, C3bR, and T lymphocytes were present in the areas with inflammatory cell infiltrate. Macrophages were found in the papillary part of the lamina propria and within the epithelium. The immunological response in the mucosa affected by denture stomatitis was in many respects similar to that of marginal and apical periodontitis. We conclude that hyperplastic denture stomatitis is a complex inflammatory lesion showing elements of both humoral and cellular immune responses.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

In situ characterization of the inflammatory cell infiltrates of hyperplastic denture stomatitis

Information for

Open access

Opportunities

Help and information

In situ characterization of the inflammatory cell infiltrates of hyperplastic denture stomatitis

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature