The Influence of Quinine on the Ampullar Receptors of the Isolated Posterior Semicircular Canal of the Frog

Abstract

The action of quinine hydrochloride on the ampullar receptors of the isolated posterior semicircular canal has been studied, using electrophysiological methods. In the Tyrode solution added with quinine hydro-chloride both the response to stimulation of the ampullar receptors and the spontaneous activity were promptly inhibited at 2.5 γ/ml of quinine hydro-chloride and almost completely blocked at 20 γ/ml. Following irrigation of solution to wash out the quinine the response to stimulation of the ampullar receptors and the spontaneous activity were slightly recovered.