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Abstract
A previously described experimental model for studying the effect of industrial solvents in the vestibular system of rabbits has been applied to rats. To achieve a constant concentration, the solvent was infused intravenously, dissolved in a lipid emulsion. Arterial blood levels were estimated by gas chromatography. The vesti-bulo-oculomotor behaviour of rats during repeated rotatory acceleration was investigated by electronystagmo-graphy. The effect of two solvents—toluene and styrene—on the rotatory induced nystagmus was examined. Both solvents caused an exaggerated reaction at arterial blood levels above 75 ppm. The investigation indicated that the rat will be a suitable species for further electronystagmo-graphic investigation on the influence of organic solvents on the vestibular system, for example in screening studies of the toxicity of these solvents.