Results of an Ultrastructural Study Comparing Stria Vascularis with Organ of Corti in Guinea Pigs Treated with Kanamycin

Abstract

Ultrastructural study of ototoxicity is well documented with two points of interest: organ of Corti for aminoglycosides and stria vascularis for loop diuretics. As a previous study suggested initial lesions of stria vascularis, an attempt of comparison and of chronological study was made between the organ of Corti and stria vascularis lesions by kanamycin intoxication. The method was devised by J. M. ARAN, with electrophysiological control. We failed to find in the stria vascularis a radial or longitudinal pattern of lesions. We could not discern a chronological injury between the organ of Corti and stria vascularis because both were damaged even in the less deafened animals. Nevertheless, two facts were clarified: (i) hair cell lesions are lysosomial as for the kidney lesions, while stria vascularis lesions are mitochondrial, (ii) melanine granulations play a part in drug metabolism (increased number, secretory aspect) and deserve further study.