Effects of Glypressin on Human Nasal Mucosa

Abstract

Bende M, Bake B, Flisberg K, Löth S, Ohlin P, Olsson P, Pipkorn U. Effects of glypressin on human nasal mucosa. Acta Otolaryngol (Stockh) 1986; 102:488–493.

The effect of intravenous and topical glypressin, a triglycyl hormonogen of vasopressin, on the nasal mucosa was evaluated in healthy subjects. A dose-dependent reduction of nasal blood flow resulted from both intravenous and topical glypressin. The effect of the latter in gel form lasted 2 hours. Glypressin was also found to decongest the nasal mucosa. Topical application of glypressin gel might be an alternative to conventional treatment with intranasal packing in nose-bleed.

Key Words:

• vasopressin
• nose
• blood flow
• rhinomanometry