Mannitol and Dextran Increase Cochlear Blood Flow in Normotensive and Spontaneously Hypertensive Rats

W. S. Quirk Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, Michigan, USA

H. A. Dengerink Department of Psychology, Washington State University, Pullman, Washington, USA

M. J. Bademian Department of Psychology, Washington State University, Pullman, Washington, USA

J. W. Wright Department of Psychology, Washington State University, Pullman, Washington, USA

Abstract

Pharmacologic treatments for otopathologies of possible vascular origin are aimed at enhancing vascular transport and are intended to increase cochlear blood flow (CBF). In the current study, normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHRs) were given intravascular infusions of mannitol (20%), dextran 70 (6%), or control saline. In general, the results clearly indicate that both osmotic agents effectively increase CBF, as measured by laser Doppler flowmetery. However, the mechanism of action of these agents is less clear.

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Mannitol and Dextran Increase Cochlear Blood Flow in Normotensive and Spontaneously Hypertensive Rats

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Mannitol and Dextran Increase Cochlear Blood Flow in Normotensive and Spontaneously Hypertensive Rats

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