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Abstract
To assess the role of a negative summating potential (— SP) in the clinical diagnosis and management of Meniere's disease, the relationship of — SP abnormality to clinical symptoms, hearing level and caloric test results was examined in 70 patients with unilateral Meniere's disease. The click-induced — SP and action potential (AP) were recorded by extratympanic electrocochleography. When SP/AP ratio exceeded 0.43, the — SP was considered to be abnormal. No significant relationship was found between abnormal - SP and clinical symptoms (the duration of cochlear and vestibular symptoms, recent hearing fluctuation and recent vertigo attack). Ears with abnormal — SP had a significantly worse hearing loss at high frequencies (2–8 kHz) than ears with normal -SP, whereas there was no significant difference in hearing loss at low frequencies (0.25–1 kHz) between both ears. No significant relation was found between abnormal -SP and abnormal unilateral weakness in caloric test. The results indicate that the click-induced — SP reflects the pathophysiology of Meniere's disease basically in the cochlear partition at high frequencies.