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International Journal of Neuroscience Volume 120, 2010 - Issue 5
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Research Article

Performance on the Clock Drawing Task Correlates with fMRI Response to a Visuospatial Task in Alzheimer's Disease

Randolph W. ParksSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UKCorrespondence[email protected]
,
Subha N. ThiyageshSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UK
,
Tom F. D. FarrowSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UK
,
Leanne IngramSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UK
,
Katherine WilkinsonSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UK
,
Michael D. HunterSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UK
,
Iain D. WilkinsonSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UK
,
Claire YoungSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UK
&
Peter W. R. WoodruffSheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield, UK
 show all
Pages 335-343 | Received 26 Feb 2007, Published online: 19 Apr 2010
 
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ABSTRACT

The clock drawing (CD) task involves visual integration skills associated with parietal lobe function. Seven mild Alzheimer's Disease (AD) patients and 11 healthy elderly controls (EC) underwent functional magnetic resonance imaging (fMRI) scanning while viewing a radial motion (RM) task. This RM task in EC activated the bilateral secondary visual cortex and parietal regions, whereas AD patients activated only the right-sided secondary visual cortex. The magnitude of the fMRI signal in the left superior parietal lobe was positively correlated with performance on the CD task in AD patients. These findings suggest that complex visuospatial processing impairments reflect the underlying AD neuropathology in parietal regions.

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