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International Journal of Neuroscience Volume 124, 2014 - Issue 12
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LETTER TO THE EDITOR

Intracerebroventricular administration of streptozotocin as an experimental approach to Alzheimer's disease

Konstantinos KalafatakisHenry Wellcome Laboratories for Integrative Neuroscience & Endocrinology, School of Clinical Sciences, Faculty of Medicine & Dentistry, University of Bristol, Bristol, UK
&
Apostolos ZarrosInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UKCorrespondence[email protected]
Pages 944-946 | Received 09 Dec 2013, Accepted 31 Jan 2014, Published online: 12 Mar 2014
 
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Abstract

The in vivo experimental simulation of Alzheimer's disease (AD) has been a field of paramount importance for Experimental Medicine and Neuroscience for more than 20 years. We herein provide a short overview of an experimental approach to sporadic AD that is based on the insulin-resistant state induced in the brains of animals following the intracerebroventricular (icv) administration of streptozotocin (STZ) at low doses. The icv administration of STZ is considered as an established, standardized and reproducible approach to sporadic AD, central aspects of the pathology of which it can reliably simulate.

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