Middle Latency Auditory Evoked Potentials in Intensive Care Patients and Normal Controls

Abstract

Evoked potentials have been introduced into intensive care unit to objectively measure parameters of coma. In particular, auditory brainstem evoked potentials have been useful for localizing brainstem dysfunction in comatose patients. The middle latency auditory evoked potentials (MLAEPs) believed to be a response of subcortical auditory radiations and the primary auditory cortex.

MLAEPs were measured in 40 adults (mean age 24.9 ± 2.9 years; range: 19-34 years) with normal hearing and in 102 intensive care patients (mean age: 48.4 ± 18.9 years; range: 14-86 years) under the influence of biological variables. Latencies (control group, mean ± SD: V = 5.74 ±. 29 ms, NO = 9.11 ± 1.74 ms, P0 = 12.94 ± 1.87 ms, Na = 17.23 ± 1.77 ms, and Pa = 29.22 ± 3.43 ms), amplitudes (control group, mean ± SE N0-P0 = 2.00 ±. 34 μV, P0-Na = 3.88 ±. 67 μV, Na-Pa = 2.83 ±. 29 μV) and the amplitude ratio (control group, mean ± SE: P0-Na/Na-Pa = 1.53 ±. 39) were calculated. In the control group in both females and males, right-sided stimulation produced shorter average MLAEP latencies and higher amplitudes than left-sided stimulation (Pa-right 28.26 ± 3.53 ms; Pa-left 30.17 ± 3.33 ms). MLAEPs showed significant differences according to sex but did not depend significantly on age. A temperature dependence was found for the latency of wave V (short latency AEP), which was prolonged at lower temperatures and for the amplitude Na-Pa, which was increased at decreased temperatures between 38.9 and 35.4°C. There was a significant association between the amplitude Na-Pa and PO₂ (P =. 017). Alterations of PCO₂ in the range of 26 to 54 mmHg did not influence the MLAEPs. Also, renal dysfunction or hepatic dysfunction and alterations of mean arterial pressure (range: 50-102 mmHg) did not affect MLAEP latencies and amplitudes significantly. Increases in latencies and decreases in amplitude were seen in sedated patients. These results in intensive care patients suggest that the combination of early AEP (acute phase) and MLAEP (post acute phase) may be useful to monitor comatose patients.

Key Words:

• middle latency auditory evoked potentials (MLAEP)
• middle latency response (MLR)
• nonnative data
• intensive care patients
• coma
• neuromonitoring