Restoration of Defective Oxygen-transport Function of Stored Red Blood Cells by Addition of Inosine

O. Åkerblom Blood Centre and Department of Clinical Chemistry and Department of Clinical Physiology, University Hospital, Uppsala, Sweden

C. H. de Verdier Blood Centre and Department of Clinical Chemistry and Department of Clinical Physiology, University Hospital, Uppsala, Sweden

L. Garby Blood Centre and Department of Clinical Chemistry and Department of Clinical Physiology, University Hospital, Uppsala, Sweden

C. Högman Blood Centre and Department of Clinical Chemistry and Department of Clinical Physiology, University Hospital, Uppsala, Sweden

Abstract

During storage of acid-citrate-dextrose-blood the oxygen affinity of the haemoglobin is increased; i.e. the oxygen dissociation curve is shifted to the left. In the meantime the red cell ATP and 2,3-diphospho-glycerate levels are decreased. In the present investigation it is shown that these changes are reversed by addition of inosine. Thus the oxygen-transport function of stored blood seems to be related to the intracorpuscular ATP and 2,3-diphosphoglycerate levels.

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Restoration of Defective Oxygen-transport Function of Stored Red Blood Cells by Addition of Inosine

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Restoration of Defective Oxygen-transport Function of Stored Red Blood Cells by Addition of Inosine

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