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Scandinavian Journal of Clinical and Laboratory Investigation Volume 21, 1968 - Issue 4
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Original Article

Effect of Administration of a Combined Estrogen-Progestin Contraceptive on the Level of Individual Plasma Proteins

C. B. Laurell Department of Clinical Chemistry and Department of Obstetrics and Gynaecology, Malmö General Hospital, University of Lund, Malmö, Sweden
,
S. Kullander Department of Clinical Chemistry and Department of Obstetrics and Gynaecology, Malmö General Hospital, University of Lund, Malmö, Sweden
&
J. Thorell Department of Clinical Chemistry and Department of Obstetrics and Gynaecology, Malmö General Hospital, University of Lund, Malmö, Sweden
Pages 337-343 | Received 01 Mar 1968, Accepted 24 Apr 1968, Published online: 08 Jul 2009
 
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Abstract

Serum proteins of 30 women were estimated before, and 6 months after, regular intake of contraceptive pills (0.1 mg mestranol and 5 mg megestrol). A highly significant rise of increasing degree was observed for α2-macroglobulin, lipoproteins, transferrin, plasminogen, α1-antitrypsin, thyroxine-binding globulin (cortisol), and ceruloplasmin. The immunoglobulins were unchanged, but albumin, haptoglobins, and orosomucoid showed a highly significant decrease. The fall of orosomucoid and haptoglobins was greater than during pregnancy, while the rise of α1-antitrypsin, α2-macroglobulin, lipoproteins, and transferrin was less. It is concluded that the metabolic effects of contraceptive steroids has not been properly explored. This study implies that these metabolic effects are only in partial agreement with the alterations occurring during normal pregnancy.

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