Glomerular Filtration Rate and Renal Plasma Flow in Short-term and Long-term Juvenile Diabetes Mellitus

Abstract

Forty-seven diabetic patients with duration of diabetes of 1 to 40 years and 31 normal subjects were investigated using classical renal clearance technique. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were significantly increased in patients with juvenile diabetes mellitus of short duration. There was no correlation between GFR and serum glucose concentration, or between GFR and serum sodium concentration. A significant decrease in both GFR and RPF was found with increasing duration of diabetes. If consistent proteinuria was not present in the long-term diabetics, no reduction could be demonstrated in GFR and RPF.

Key Words:

• Diabetes
• diabetic nephropathy
• inulin
• kidney function
• kidney glomerulus
• PAH