Plasma Proteins after Use of Estrogen and/or Progestogen in Women with and without Recurrent Cholestasis during Previous Pregnancies

Abstract

The authors report the concentration of some plasma proteins after administration of mestranol and/or chlormadinone in 19 controls and 43 women who had had recurrent cholestasis during previous pregnancies. Mestranol alone and combined with chlormadinone acetate induced enhanced β_IC-globulin and fibrinogen and depressed cold insoluble globulin level. The changes were, if anything, more marked in women with cholestasis during an earlier pregnancy. No change of antichymotrypsin or C-reactive proteins was found in any of the groups. Chlormadinone acetate alone produced no apparent alterations in the plasma protein pattern.

Key Words:

• Antichymotrypsin
• chlormadinone
• contraceptive steroids
• C-reactive protein
• fibrinogen
• β_IC-globulin
• mestranol
• plasma protein