11
Views
4
CrossRef citations to date
0
Altmetric
Miscellaneous Article

Intravenous Infusion of Inosine in Man: Effect on Erythrocyte 2,3-Diphosphoglycerate Concentration and on Blood Oxygen Affinity

&
Pages 205-210 | Received 19 Mar 1973, Accepted 20 Aug 1973, Published online: 08 Jul 2009
 

Abstract

Ten mmol each of inosine and inorganic phosphate were infused intravenously to two volunteers. The concentrations of 2,3-diphosphoglycerate, fructose 1,6-diphosphate, and ATP in erythrocytes were analyzed during the infusion period (1 hour) and the following 24 hours. Fructose 1,6-diphosphate reached a maximal value four times the normal immediately after infusion. The concentration declined rapidly and was normal after one hour. The content of 2,3-diphosphoglycerate increased and decreased more slowly. The maximal value –- about 8% above the normal level of the individual –- was reached 3 hours after the infusion ended. The increase of 2,3-diphosphoglycerate concentration was too small to give a measurable right shift of the oxyhemoglobin dissociation curve. The fact that S-urate rose 0.3 mmol/l prevents further increase of the inosine dose. Pretreatment with allopurinol reduced the concentration changes of the erythrocyte metabolites.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.