Effects of different doses of acetylsalicylic acid on renal oxygen consumption

Abstract

The aim of the present study was to examine the acute effect of acetylsalicylic acid (ASA) on renal oxygen consumption (Qo₂) and renal sodium excretion (U_N.V) in anaesthetized dogs. With plasma salicylic acid (SA) concentrations ranging from 200-400 μg/ml, Q_o2 increased 36% (P<005) in spite of a 16% decrease in renal blood flow. At plasma SA concentrations of 80-200 μg/ml Q_o2 was significantly increased 45 min after the onset of ASA infusion. U_NaV decreased from 97.7 to 21.5 μmol/min (P<005). Glomerular filtration rate and absolute tubular reabsorption of sodium (R_Na) was unchanged. The ratio RNa/Q_o2 decreased from 31.0 to 21.3 (P<005). Renal lactate uptake increased. The results are most consistent with an uncoupling effect of ASA on oxidative phosphorylation in the kidney.

Key Words:

• acetylsalicylic acid
• oxidative phosphorylation
• renal blood flow
• renal oxygen consumption
• tubular reabsorption of sodium