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Abstract
Five young male patients with exercise-induced asthma (EIA) were subjected to graded bicycle exercise with work loads corresponding to 50%, 75% and 120% of the load necessary to elicit maximal oxygen uptake (V¯o2 max). The exercise tests were performed after inhalation of salbutamol (Ventolineα) as well as after inhalation of saline as control. Additionally two maximal work tests (bicycling and treadmill) were performed without inhalation on a work load corresponding to 100% V¯o2 max. Oxygen uptake v¯o2 heart rate (HR), mean blood pressure (MBP), rating of perceived exertion (RPE) as well as arterial concentration of glucose and acid-base variables were measured. v¯o2 max during bicycle exercise averaged 3.16 1/min and no significant difference was disclosed between the β2-stimulation and the control situations. The coefficient of variation of a single v¯o2 max measurement was 4.7%. The maximal treadmill running revealed a significantly higher v¯o2 max (3.42 1/min, P<0.05) than during bicycling; no EIA was provoked in any of the experiments. After β2-stimulation a higher HR and MBP in relation to v¯o2 was observed than in the control experiment; however, the slope of HR/v¯o2 and MBP/v¯o2 relationships was not affected. Normal relationships were observed between v¯o2 and work load, ventilation, RPE and acid-base data and these relations were unaffected of β2-stimulation. It is concluded, that v¯o2 max seems to be within the normal range in asthmatics, provided they are free from attacks.