Determination of the tissue-to-blood partition coefficient for ¹³¹iodo-antipyrine in human subcutaneous adipose tissue

Abstract

¹³¹Iodo-antipyrine (¹³¹I-AP) is commonly used for blood flow measurements in adipose tissue. These estimations have been based on the assumption of the tissue-to-blood partition coefficient being 1 ml g^-1. No exact determination of the tissue-to-blood partition coefficient for ¹³¹I-AP in adipose tissue has been carried out. In the present study a partition coefficient of 1.12±0.06 (mean±S.D.) for ¹³¹I-AP in adipose tissue has been determined based on the partition coefficient for ¹³¹I-AP between lipid-saline (1.24 ml g^-1), red blood cells-plasma (0.64 ml g^-1), protein-saline (0.19 ml g^-1) and plasma-saline (0.84 ml ml^-1).

Key Words:

• ¹³¹iodo-antipyrine
• partition coefficient
• subcutaneous adipose tissue