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Original Article

Budesonide as first-line therapy for non-cirrhotic autoimmune hepatitis in children: a decision analysis

Pages 753-762 | Received 23 Oct 2015, Accepted 06 Dec 2015, Published online: 14 Jan 2016
 

ABSTRACT

Objective Therapy for autoimmune hepatitis has been prednisone based for decades; however, budesonide may be equally effective with fewer side effects. Our aim was to evaluate quality-adjusted life years and health care costs of three different treatment regimens. Materials and methods Treatment using prednisone, budesonide or a combination of both over a three-year period in newly diagnosed children with type I autoimmune hepatitis were simulated with a Markov model. Transition probabilities were calculated over consecutive three-month period. Costs were determined from a hospital database and health utilities were estimated from the literature. A Monte Carlo probabilistic sensitivity analysis was used to simulate the outcomes of 5000 patients in each treatment arm. Results Compared to standard therapy, budesonide leads to a gain of 0.09 quality-adjusted life years, costing $17,722 per QALY over a three-year period. Standard therapy led to significantly lower QALY’s compared to other strategies (p < 0.001). Health utilities of patients in remission in each treatment group had the greatest impact on the model. Budesonide remained the treatment of choice if the probability of inducing remission was 55% or greater. Conclusions Budesonide therapy in non-cirrhotic, treatment naïve patients with type I autoimmune hepatitis yielded greater QALY’s compared to the current standard therapy with an acceptable increase in costs.

Disclosure statement

The author reports no conflicts of interest. The author alone is responsible for the content and writing of this article.

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