Effect of Vagotomy on the Canine Pancreatic Secretion after Feeding

Abstract

The effect of vagotomy on the external pancreatic secretion in response to a meat meal was investigated in 5 dogs with duodenal and gastric Thomas cannulas. Precautions were taken to maintain the normal regulation of neutrality in the duodenum during the post-prandial period. The gastric acid secretion was determined in some experiments. After vagotomy the secretion of gastric acid and pancreatic fluid and bicarbonate were reduced to the same degree, about 85 %, while the pancreatic secretion of protein was only reduced 57 %. Cholinergic stimulation with Urecholine increased the pancreatic secretion of fluid and bicarbonate to pre-vagotomy levels. The protein secretion did not attain that level, indicating an impaired protein secretion.

Key-words:

• Meal stimulation
• pancreas
• pancreatic secretion
• vagotomy