Effects of 16,16 Dimethyl Prostaglandin E₂ on Food-stimulated Pancreatic Secretion and Output of Bile in Man

Abstract

The effect of 140 μg 16,16 dimethyl prostaglandin E₂ on food-stimulated pancreatic and biliary response has been studied in 7 healthy subjects, using a multiple indicator dilution technique. Intragastric administration of the methyl analogue decreased significantly the pancreatic and the biliary response, despite an enhanced gastric emptying rate of the test meal.

Key-words:

• Bilirubin excretion
• gastric emptying
• indicator dilution technique
• pancreatic secretion