Indomethacin Treatment of Acute Experimental Pancreatitis in the Rat

P. G. Lankisch Division of Gastroenterology and Metabolism, Dept. of Medicine, University of Göttingen, and Max-Planck-Institute for Experimental Medicine, Göttingen, West Germany

H. Koop Division of Gastroenterology and Metabolism, Dept. of Medicine, University of Göttingen, and Max-Planck-Institute for Experimental Medicine, Göttingen, West Germany

K. Winckler Division of Gastroenterology and Metabolism, Dept. of Medicine, University of Göttingen, and Max-Planck-Institute for Experimental Medicine, Göttingen, West Germany

H. Kunze Division of Gastroenterology and Metabolism, Dept. of Medicine, University of Göttingen, and Max-Planck-Institute for Experimental Medicine, Göttingen, West Germany

W. Vogt Division of Gastroenterology and Metabolism, Dept. of Medicine, University of Göttingen, and Max-Planck-Institute for Experimental Medicine, Göttingen, West Germany

Abstract

Indomethacin given orally or intramuscularly before or shortly after induction of acute sodium-taurocholate or olive-oil-induced pancreatitis in rats reduced the lethality. Neither the enzyme content of serum, ascites, and pancreatic tissue nor the damage to the organ itself were changed under the influence of indomethacin. Thus a modification of systemic effects of acute pancreatitis may be responsible for the beneficial effect of indomethacin.

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Notes

*Preliminary results of this study have been presented at the 10th Symposium of the European Pancreatic Club, Dublin, October 1977 (12).

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Indomethacin Treatment of Acute Experimental Pancreatitis in the Rat

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Indomethacin Treatment of Acute Experimental Pancreatitis in the Rat

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