Fat-Induced Jejunal Inhibition of Gastric Acid Secretion and Release of Pancreatic Glucagon, Enteroglucagon, Gastric Inhibitory Polypeptide, and Vasoactive Intestinal Polypeptide in Man

J. Christiansen Dept. of Surgery D, Glostrup Hospital, Dept. of Clinical Chemistry, Bispebjerg Hospital, Novo Research Laboratories, Institute of Medical Physiology C, University of Copenhagen, and Dept. of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark

A. Bech Dept. of Surgery D, Glostrup Hospital, Dept. of Clinical Chemistry, Bispebjerg Hospital, Novo Research Laboratories, Institute of Medical Physiology C, University of Copenhagen, and Dept. of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark

J. Fahrenkrug Dept. of Surgery D, Glostrup Hospital, Dept. of Clinical Chemistry, Bispebjerg Hospital, Novo Research Laboratories, Institute of Medical Physiology C, University of Copenhagen, and Dept. of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark

J. J. Holst Dept. of Surgery D, Glostrup Hospital, Dept. of Clinical Chemistry, Bispebjerg Hospital, Novo Research Laboratories, Institute of Medical Physiology C, University of Copenhagen, and Dept. of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark

K. Lauritsen Dept. of Surgery D, Glostrup Hospital, Dept. of Clinical Chemistry, Bispebjerg Hospital, Novo Research Laboratories, Institute of Medical Physiology C, University of Copenhagen, and Dept. of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark

A. J. Moody Dept. of Surgery D, Glostrup Hospital, Dept. of Clinical Chemistry, Bispebjerg Hospital, Novo Research Laboratories, Institute of Medical Physiology C, University of Copenhagen, and Dept. of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark

O. Schaffalitzky de Muckadell Dept. of Surgery D, Glostrup Hospital, Dept. of Clinical Chemistry, Bispebjerg Hospital, Novo Research Laboratories, Institute of Medical Physiology C, University of Copenhagen, and Dept. of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark

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Abstract

The effect of intrajejunal (i.j.) infusion of fat on meal-stimulated gastric acid secretion and release of pancreatic glucagon (PG), enteroglucagon (EG), gastric inhibitory polypeptide (GIP), and vasoactive intestinal polypeptide (VIP) was studied in seven healthy volunteers. I.j. fat markedly inhibited meal-stimulated acid secretion as compared to a control study with i.j. saline infusion. The acid inhibition was accompanied by augmented plasma concentrations of EG, GIP, and VIP but not of PG, suggesting that EG, GIP, and VIP may be among mediators of fat-induced jejunal inhibition of acid secretion. Concentration-time relationship makes it unlikely that the observed inhibition could be ascribed to any single peptide studied.

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Fat-Induced Jejunal Inhibition of Gastric Acid Secretion and Release of Pancreatic Glucagon, Enteroglucagon, Gastric Inhibitory Polypeptide, and Vasoactive Intestinal Polypeptide in Man

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Fat-Induced Jejunal Inhibition of Gastric Acid Secretion and Release of Pancreatic Glucagon, Enteroglucagon, Gastric Inhibitory Polypeptide, and Vasoactive Intestinal Polypeptide in Man

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