Plasma Gastrin Concentrations following Sham Feeding in Duodenal Ulcer Patients

B. Stenquist Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Dept. of Physiology, Faculty of Veterinary Medicine, The Swedish University of Agricultural Sciences. Uppsala, and Dept. of Experimental Surgery, Serafimerlasarettet, Stockholm, Sweden, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

G. Nilsson Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Dept. of Physiology, Faculty of Veterinary Medicine, The Swedish University of Agricultural Sciences. Uppsala, and Dept. of Experimental Surgery, Serafimerlasarettet, Stockholm, Sweden, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

J. F. Rehfeld Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Dept. of Physiology, Faculty of Veterinary Medicine, The Swedish University of Agricultural Sciences. Uppsala, and Dept. of Experimental Surgery, Serafimerlasarettet, Stockholm, Sweden, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

L. Olbe Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Dept. of Physiology, Faculty of Veterinary Medicine, The Swedish University of Agricultural Sciences. Uppsala, and Dept. of Experimental Surgery, Serafimerlasarettet, Stockholm, Sweden, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

Abstract

Sham feeding experiments were performed in 20 duodenal ulcer (DU) patients by using adequate sham feeding and modified sham feeding (the ‘chew-and-spit’ technique). A 15-min sham feeding induced a marked secretion of gastric acid but only an insignificant increase in total gastrin or in gastrin₁₇ concentrations in plasma. Nor did prolonged sham feeding (30 min) with intragastric neutralization significantly increase the gastrin concentrations. We conclude that sham feeding in DU patients induces a release of recognized gastrin components in amounts that are barely detectable radioimmunologically. Therefore, the acid secretory effect of vagally released gastrins in DU patients remains to be established.

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Plasma Gastrin Concentrations following Sham Feeding in Duodenal Ulcer Patients

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Plasma Gastrin Concentrations following Sham Feeding in Duodenal Ulcer Patients

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