Protection by Trimipramine Against Gastric Mucosal Barrier Dysfunction Induced by Ethanol + HCl in Rats

Abstract

The effects of trimipramine (5 mg · kg⁻¹·h⁻¹ intravenously) on the changes in gastric mucosal function evoked by 20% ethanol + HCl has been studied in rats. The magnitude of the changes in potential difference, ionic fluxes (H⁺, Na⁺, and K⁺), and mucosal lesion score induced by ethanol + HCl were significantly less in animals treated with trimipramine than in control animals. It is concluded that trimipramine decreases the gastric mucosal damage produced by ethanol + HCl in rats. This activity may be responsible, at least in part, for the beneficial effect of trimipramine treatment in peptic ulcer disease.

Key-words:

• Gastric ulcer
• stomach
• trimipramine