Fine-Morphology of Chief Cells in Human Gastric Mucosa after Secretin

J. Stachura Veterans Administration Medical Center, Long Beach, and University of California, Irvine, California, and Dept. of Anatomy, University of Missouri, Columbia, Missouri, USA

K. J. Ivey Veterans Administration Medical Center, Long Beach, and University of California, Irvine, California, and Dept. of Anatomy, University of Missouri, Columbia, Missouri, USA

A. Tarnawski Veterans Administration Medical Center, Long Beach, and University of California, Irvine, California, and Dept. of Anatomy, University of Missouri, Columbia, Missouri, USA

W. J. Krause Veterans Administration Medical Center, Long Beach, and University of California, Irvine, California, and Dept. of Anatomy, University of Missouri, Columbia, Missouri, USA

P. Stogsdill Veterans Administration Medical Center, Long Beach, and University of California, Irvine, California, and Dept. of Anatomy, University of Missouri, Columbia, Missouri, USA

Abstract

Quantitative ultrastructural studies of human gastric mucosal chief cells during secretory stimulation have not been reported previously. In five healthy subjects we studied the effect of intravenous administration of 2 CU/kg of GIH secretin on gastric chief-cell ultrastructure. Gastric biopsies for quantitative ultrastructural analysis were obtained before and 15 and 30 min after secretin administration. Electron micrographs of 150 chief cells were analyzed by the Loud quantitative method. After secretin administration the percentage area occupied by zymogen granules decreased significantly at 15 and 30 min. At corresponding times membrane profile concentration (rough endoplasmic reticulum) increased significantly over basal values. This study provides morphological evidence of increased activity of chief cells after secretin administration.

Key-words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Fine-Morphology of Chief Cells in Human Gastric Mucosa after Secretin

Information for

Open access

Opportunities

Help and information

Fine-Morphology of Chief Cells in Human Gastric Mucosa after Secretin

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature