Treatment of Reflux Oesophagitis with a Carbenoxolone/ Antacid/Alginate Preparation: A Double-Blind Controlled Trial

G. P. Young Dept. of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia; Western General Hospital, Footscray, Victoria, Australia; Royal North Shore Hospital, Sydney, New South Wales, Australia; Ullevål University Hospital, Oslo, Norway; University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland; Wexham Park Hospital, Slough, England

G. S. Nagy Dept. of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia; Western General Hospital, Footscray, Victoria, Australia; Royal North Shore Hospital, Sydney, New South Wales, Australia; Ullevål University Hospital, Oslo, Norway; University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland; Wexham Park Hospital, Slough, England

J. Myren Dept. of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia; Western General Hospital, Footscray, Victoria, Australia; Royal North Shore Hospital, Sydney, New South Wales, Australia; Ullevål University Hospital, Oslo, Norway; University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland; Wexham Park Hospital, Slough, England

I. J. Kronborg Dept. of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia; Western General Hospital, Footscray, Victoria, Australia; Royal North Shore Hospital, Sydney, New South Wales, Australia; Ullevål University Hospital, Oslo, Norway; University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland; Wexham Park Hospital, Slough, England

K. R. Logan Dept. of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia; Western General Hospital, Footscray, Victoria, Australia; Royal North Shore Hospital, Sydney, New South Wales, Australia; Ullevål University Hospital, Oslo, Norway; University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland; Wexham Park Hospital, Slough, England

P. I. Reed Dept. of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia; Western General Hospital, Footscray, Victoria, Australia; Royal North Shore Hospital, Sydney, New South Wales, Australia; Ullevål University Hospital, Oslo, Norway; University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland; Wexham Park Hospital, Slough, England

J. L. Hopper Dept. of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia; Western General Hospital, Footscray, Victoria, Australia; Royal North Shore Hospital, Sydney, New South Wales, Australia; Ullevål University Hospital, Oslo, Norway; University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland; Wexham Park Hospital, Slough, England

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Abstract

Twenty-nine patients were treated with a carbenoxolone/antacid/alginate preparation (Pyrogastrone®) and 30 with antacid/alginate alone four times each day for 8 weeks, in a double-blind study, to ascertain the value of carbenoxolone in the treatment of patients with endoscopically confirmed reflux oesophagitis. Symptom review every 2 weeks and endoscopic findings every 4 weeks were converted to a 6-point grading system to facilitate statistical comparison, using a stochastic model for predicting the rate of change in grades during treatment. Carbenoxolone-treated patients showed an 82% improvement in symptom grades over 8 weeks and improved 50% faster (P< 0.01) than did control patients, who showed a 63% improvement. Endoscopic improvement was not significantly different in the first 4 weeks, although healing was better maintained in carbenoxolone-treated patients during the second 4 weeks (P < 0.05). At the low doses used (5 × 20mg daily) no significant side effects of carbenoxolone were encountered. Pyrogastrone should be considered as a therapeutic alternative in patients who fail to respond to routine management with antacids.

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Source: Springer Science and Business Media LLC

REVIEW: BARRIER TREATMENTS IN ACID REFLUX DISORDERS

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Treatment of Reflux Oesophagitis with a Carbenoxolone/ Antacid/Alginate Preparation: A Double-Blind Controlled Trial

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