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Scandinavian Journal of Gastroenterology Volume 21, 1986 - Issue sup118
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Original Article

Pharmacokinetics and Metabolism of Omeprazole in Animals

I Skånberg Department of Pharmacokinetics and Drug Metabolism, AB Hässle, Mölndal, Sweden
,
K-J Hoffmann Department of Pharmacokinetics and Drug Metabolism, AB Hässle, Mölndal, Sweden
&
C G Regårdh Department of Pharmacokinetics and Drug Metabolism, AB Hässle, Mölndal, Sweden
Pages 92-93 | Published online: 08 Jul 2009
 
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Abstract

The pharmacokinetics and metabolism of omeprazole have been studied to varying extents in the mouse, rat and dog. Certain substituted benzimidazoles have been shown to be inhibitors of the hepatic microsomal mono-oxygenases (1). The inhibitory effect of omeprazole has been studied in vitro and in vivo in the rat.

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