Total Parenteral Nutrition and the Function of the Intestinal Microflora in Crohn's Disease

C. E. Leijonmarck Dept. of Surgery, S:t Görans Hospital; Dept. of Surgery, Nacka Hospital, Stockholm, Sweden; Dept. of Medical Microbial Ecology, Karolinska Institutet Stockholm, Sweden

L. O. Bergstrand Dept. of Surgery, S:t Görans Hospital; Dept. of Surgery, Nacka Hospital, Stockholm, Sweden; Dept. of Medical Microbial Ecology, Karolinska Institutet Stockholm, Sweden

B. Carlstedt-Duke Dept. of Surgery, S:t Görans Hospital; Dept. of Surgery, Nacka Hospital, Stockholm, Sweden; Dept. of Medical Microbial Ecology, Karolinska Institutet Stockholm, Sweden

A. Gustafsson Dept. of Surgery, S:t Görans Hospital; Dept. of Surgery, Nacka Hospital, Stockholm, Sweden; Dept. of Medical Microbial Ecology, Karolinska Institutet Stockholm, Sweden

A. C. Midtvedt Dept. of Surgery, S:t Görans Hospital; Dept. of Surgery, Nacka Hospital, Stockholm, Sweden; Dept. of Medical Microbial Ecology, Karolinska Institutet Stockholm, Sweden

K. E. Norin Dept. of Surgery, S:t Görans Hospital; Dept. of Surgery, Nacka Hospital, Stockholm, Sweden; Dept. of Medical Microbial Ecology, Karolinska Institutet Stockholm, Sweden

H. Saxerholt Dept. of Surgery, S:t Görans Hospital; Dept. of Surgery, Nacka Hospital, Stockholm, Sweden; Dept. of Medical Microbial Ecology, Karolinska Institutet Stockholm, Sweden

T. Midtvedt Dept. of Surgery, S:t Görans Hospital; Dept. of Surgery, Nacka Hospital, Stockholm, Sweden; Dept. of Medical Microbial Ecology, Karolinska Institutet Stockholm, Sweden

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Abstract

The effect of total parenteral nutrition (TPN) on the following six intestinal micro-flora-associated characteristics (MACs) was studied in patients with Crohn's disease: faecal tryptic activity (FTA), formation of coprostanol, urobilinogen, and deoxycholic acid, and degradation of mucin and β-aspartylglycine. The FTA showed high levels before TPN, in accordance with previous findings, and decreased during TPN. Formation of coprostanol, urobilinogen, and deoxycholic acid was reduced in some patients, whereas no changes were found in the mucin and β-aspartylglycine degradation.

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Total Parenteral Nutrition and the Function of the Intestinal Microflora in Crohn's Disease

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Total Parenteral Nutrition and the Function of the Intestinal Microflora in Crohn's Disease

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