The Effects of Famotidine, 40 mg at Night, on 24-Hour Intragastric Acidity and Plasma Gastrin Concentration in Healthy Subjects

Abstract

Lanzon-Miller S, Pounder RE, Ball SG, Dalgleish DJ, Coward J, Jackson AO. The effects of famotidine, 40 mg at night, on 24-h intragastric acidity and plasma gastrin concentration in healthy subjects.

The effects of 40 mg oral famotidine at 2115 h on 24–h intragastric acidity and plasma gastrin concentration were measured in a double-blind placebo-controlled study in 10 healthy subjects. The subjects were studied on the 7th day of treatment with either famotidine or placebo. Famotidine, 40 mg at night, caused a pulse of decreased intragastric acidity during the night, with a longer-lasting elevation of plasma gastrin concentration. However, in the latter part of the day there was complete recovery from the antisecretory effects of the drug, with normal intragastric acidity and normal concentrations of plasma gastrin.

Key Words:

• Famotidine
• gastric carcinoids
• gastrin
• 24-h acidity