Histochemistry of the Gastric and Duodenal Mucosa under Cimetidine and Carbenoxolone Treatment

Abstract

Histological and histochemical patterns of the gastric and duodenal mucosa was investigated in nine subjects with duodenal ulcer or ulcerlike syndrome after 4 to 5 weeks treatment with cimetidine or carbenoxolone. No spectacular changes were found after carbenoxolone except for a slight increase in goblet cells in the duodenal bulb. In the patients treated with cimetidine, findings suggesting an influence of this drug on the biochemical cytology of parietal cells and some interference in the differentiation of enterocytes were established.

Key Words:

• Carbenoxolone
• cimetidine
• duodenal mucosa
• gastric mucosa
• histochemistry