Pancreatic Secretion and the Release of Cholecystokinin after a Meal in Dogs with and without Exclusion of Pancreatic Juice

M. Kogire First Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan; Dept. of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA

K. Inoue First Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan; Dept. of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA

R. Hosotani First Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan; Dept. of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA

Y.-S. Huang First Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan; Dept. of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA

J. C. Thompson First Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan; Dept. of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA

T. Tobe First Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan; Dept. of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA

Abstract

Pancreatic secretion and plasma levels of cholecystokinin-33/39 (CCK) were measured for 5 h after a meal in dogs with and without exclusion of pancreatic juice. Significant and prolonged increases in pancreatic secretion and plasma CCK levels were observed irrespective of pancreatic juice exclusion. The integrated responses of pancreatic protein output (2.6 ± 0.6g/300min), plasma CCK (1.3 ± 0.5 nmol×l^-1 ×300 min) with exclusion of pancreatic juice showed no significant differences from those without exclusion (2.8 ± 0.3 g/300 min and 1.3 ± 0.3 nmol×l^-1.300 min for protein output and CCK, respectively). These results suggest that the CCK-mediated feedback mechanism of pancreatic enzyme secretion does not work, at least not in the postprandial state in dogs.

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Pancreatic Secretion and the Release of Cholecystokinin after a Meal in Dogs with and without Exclusion of Pancreatic Juice

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Pancreatic Secretion and the Release of Cholecystokinin after a Meal in Dogs with and without Exclusion of Pancreatic Juice

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