Repeated Intravenous Bolus Injections of Omeprazole: Effects on 24-Hour Intragastric pH, Serum Gastrin, and Serum Pepsinogen A and C

Abstract

We determined the effect of four times daily dosing with intravenous omeprazole on 24-h intragastric acidity, serum gastrin, and serum pepsinogen A and C in 10 fasting subjects (median age, 23.5 years). Two dose regimens (80-20-20-20 mg and 80-40-40-40 mg) were compared in a randomized placebo-controlled crossover study. Intragastric pH was continuously monitored during 24 h, using combined glass electrodes, and blood samples were taken every 6 h. Repeated boluses of omeprazole every 6 h significantly increased (p < 0.01) the median 24-h intragastric pH compared with placebo (median pH, 3.7 (140mg/day), 4.3 (200mg/day), and 1.4 (placebo)) but failed to continuously raise pH levels above 4.0 in 8 (140 mg/day) or 9 (200 mg/ day) of 10 subjects. No advantage of the 200-mg dose over the 140-mg dose was demonstrated. A cumulative effect of intravenous omeprazole was shown after repeated boluses but also a marked interindividual variation in response, which was correlated with the omeprazole area under the plasma concentration time curve. A significant elevation of serum gastrin coincided with the increased pH levels, which was followed after 12-18 h by a significant increase of both serum pepsinogens.

Key Words:

• Anti-ulcer agent
• drug administration schedule
• gastric acid determination
• gastrins
• intravenous infusions
• omeprazole
• pepsinogens
• pH