Relative Importance of Pancreatic, Hepatic, and Mucosal Bicarbonate in Duodenal Neutralization of Acid in Anaesthetized Pigs

M. A. Ainsworth Depts. of Medical and Surgical Gastroenterology, Odense University Hospital, and Biomedical Laboratory, Odense University, Odense; Dept. of Clinical Chemistry and Dept. of Surgery C, Rigshospitalet, Copenhagen, Denmark

P. Svendsen Depts. of Medical and Surgical Gastroenterology, Odense University Hospital, and Biomedical Laboratory, Odense University, Odense; Dept. of Clinical Chemistry and Dept. of Surgery C, Rigshospitalet, Copenhagen, Denmark

L. Ladegaard Depts. of Medical and Surgical Gastroenterology, Odense University Hospital, and Biomedical Laboratory, Odense University, Odense; Dept. of Clinical Chemistry and Dept. of Surgery C, Rigshospitalet, Copenhagen, Denmark

P. Cantor Depts. of Medical and Surgical Gastroenterology, Odense University Hospital, and Biomedical Laboratory, Odense University, Odense; Dept. of Clinical Chemistry and Dept. of Surgery C, Rigshospitalet, Copenhagen, Denmark

O. Olsen Depts. of Medical and Surgical Gastroenterology, Odense University Hospital, and Biomedical Laboratory, Odense University, Odense; Dept. of Clinical Chemistry and Dept. of Surgery C, Rigshospitalet, Copenhagen, Denmark

O. B. Schaffalitzky de Muckadell Depts. of Medical and Surgical Gastroenterology, Odense University Hospital, and Biomedical Laboratory, Odense University, Odense

Abstract

Pancreatic and hepatic bicarbonate secretion and the disappearance rate of acid during duodenal acidification were measured simultaneously in anaesthetized pigs. Perfusion of the duodenum with HCI resulted in an increase in both hepatic and pancreatic bicarbonate secretion. During all acid loads hepatic bicarbonate secretion was significantly greater than pancreatic secretion. Furthermore, the disappearance rate of acid in the duodenum during diversion of both bile and pancreatic juice was significantly greater than the amount of acid which could be neutralized by the concomitant pancreatic bicarbonate secretion. Diversion of pancreatic juice from the duodenum did not affect the disappearance rate of acid at any acid load, whereas diversion of bile caused a significant decrease. Thus, in the anaesthetized pig the liver and the duodenal mucosa are of greater importance than the pancreas for the neutralization of acid in the duodenum. It is suggested that the importance of the pancreatic contribution to duodenal neutralization should be reevaluated in other species, including man.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Relative Importance of Pancreatic, Hepatic, and Mucosal Bicarbonate in Duodenal Neutralization of Acid in Anaesthetized Pigs

Information for

Open access

Opportunities

Help and information

Relative Importance of Pancreatic, Hepatic, and Mucosal Bicarbonate in Duodenal Neutralization of Acid in Anaesthetized Pigs

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature