Does Vagotomy Affect the Growth of the Pancreas in the Rat?

D. Chen Depts. of Pharmacology and Surgery, University of Lund, Lund, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark

A. G. Nylander Depts. of Pharmacology and Surgery, University of Lund, Lund, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark

J. F. Rehfeld Depts. of Pharmacology and Surgery, University of Lund, Lund, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark

J. Axelson Depts. of Pharmacology and Surgery, University of Lund, Lund, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark

I. Ihse Depts. of Pharmacology and Surgery, University of Lund, Lund, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark

R. Håkanson Depts. of Pharmacology and Surgery, University of Lund, Lund, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark

Abstract

Chen D, Nylander A-G, Rehfeld JF, Axelson J, Ihse I, Hakanson R. Does vagotomy affect the growth of the pancreas in the rat? Scand J Gastroenterol 1992;27:606-608.

Vagotomy has been claimed to have a growth-promoting effect on the pancreas in the rat. The present study failed to show differences in total or relative pancreatic weight and DNA content between vagally intact and vagally denervated rats, whether normoCCKemic or hyperCCKemic after pancreaticobiliary diversion during 2-8 weeks. Contrary to the claims made in several recent reports, vagotomy does not seem to influence the growth of the rat pancreas.

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Does Vagotomy Affect the Growth of the Pancreas in the Rat?

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Does Vagotomy Affect the Growth of the Pancreas in the Rat?

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