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Abstract
Background: Our aim was to investigate the effect of endoscopic injection therapy on the clinical outcome of patients with benign peptic ulcer bleeding. Methods: In this study 1203 patients admitted with peptic ulcer bleeding over a 5-year period (January 1987 to April 1991) before endoscopic therapy and 1028 patients admitted with peptic nicer bleeding alter introduction of endoscopic therapy (May 1991 to March 1996) were assessed. Endoscopic therapy was performed in all patients with active bleeding or non-bleeding visible vessels during emergency endoscopy with injection of adrenaline. 1:10,000 in 0.9% saline. Results: The introduction of injection therapy was associated with a reduction in transfusion requirements (from 5.1 ± 2.6 to 3.4 ± 1.8 units), hospitalization days (from 10.8 ± 6.5 to 7.8 ± 5.1 days), surgical interventions (from 50.6% to 23.6%), and mortality (from 12.9% to 4.6%) in patients with active bleeding or non-bleeding visible vessels (P < 0.05) but remained unchanged in the rest. Patients with gastric ulcer had a more pronounced reduction in emergency surgical haemostasis and mortality than patients with duodenal ulcer. There were no deaths or procedure-related complications. Conclusion: Endoscopic injection therapy with adrenaline saline is a simple, low-cost, and sale method that improves the clinical outcome and reduces the mortality in patients with peptic ulcer bleeding.