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Scandinavian Journal of Infectious Diseases Volume 42, 2010 - Issue 8
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CASE REPORT

Heparin-binding protein as a biomarker of circulatory failure during severe infections: A report of three cases

Ondřej Beran Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and University Hospital Bulovka, Czech Republic
,
Heiko Herwald Department of Clinical Science, Division of Infection Medicine, Lund University, Sweden
,
Olga Džupová Department of Infectious Diseases, Third Faculty of Medicine, Charles University in Prague and University Hospital Bulovka, Czech Republic
,
Pavel Chalupa Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and University Hospital Bulovka, Czech Republic
&
Michal Holub Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and University Hospital Bulovka, Czech RepublicCorrespondence[email protected]
Pages 634-636 | Received 24 Feb 2010, Accepted 26 Feb 2010, Published online: 29 Apr 2010
 
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Abstract

We report 3 cases of disease – leptospirosis, tropical malaria and fulminant meningococcaemia – associated with high serum concentrations of heparin-binding protein (HBP) and haemodynamic instability. Furthermore, HBP kinetics were observed for the first 3 days in survivors and were correlated with improvement in clinical condition.

Acknowledgements

The study was supported by grant IGA NR/9316-3 from the Ministry of Health of the Czech Republic and by grant MSM 0021620806 from the Ministry of Youth, Education and Sports of the Czech Republic.

Declaration of interest: Hansa Medical (Lund, Sweden) has filed patent applications on HBP as a diagnostic target, and HH is listed as one of the inventors. The application is pending. The remaining authors declare no competing financial interests.

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