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Research Article

Altered phosphate metabolism in HIV-1-infected patients with metabolic syndrome

, , , , , , & show all
Pages 133-137 | Received 26 Apr 2011, Accepted 08 Sep 2011, Published online: 08 Nov 2011
 

Abstract

Background: Metabolic syndrome (MS) represents a cluster of cardiovascular risk factors that has become a serious problem for HIV-1-infected patients. It has been proposed that disturbance of phosphate metabolism may represent a key feature of MS. Thus, we undertook the present study to investigate the relationship between phosphate levels and the presence of the characteristics of MS. Methods: One hundred and twenty-one HIV-1-infected patients were consecutively enrolled in a prospective, cross-sectional, single-centre study. Kidney tubular function was examined using tubular resorption of phosphate and normalized renal threshold phosphate concentration. Results: Univariate analysis showed that serum phosphate levels correlated negatively with systolic and diastolic blood pressure, glucose values, waist circumference, insulin, and triglycerides. Moreover, there was a positive relationship between phosphate and high-density lipoprotein (HDL) cholesterol. Multivariate analysis showed that insulin levels were correlated with serum phosphate concentration (r = − 0.24, p = 0.01). Conclusions: Our data show that HIV-1-infected patients with MS have lower phosphate levels.

Declaration of interest: The authors declare that no funding was received. The authors declare that they have no competing interests.

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