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Scandinavian Journal of Infectious Diseases Volume 44, 2012 - Issue 8
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Case Reports

Pharmacokinetics and administration method of gentamicin in a patient on haemodialysis

Yoichi HirakiDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, KumamotoCorrespondence[email protected]
,
Mikako HiraikeDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto
,
Masahisa NaganoDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto
,
Yukari OzonoDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto
,
Kenichi ManabeDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto
,
Nobuhiro MisumiDepartment of Pharmacy, National Hospital Organization Kyushu Medical Center, Fukuoka City, Fukuoka
,
Yasuhiro TsujiDepartment of Pharmacy, Sasebo Chuo Hospital, Sasebo, Nagasaki
,
Hidetoshi KamimuraDepartment of Pharmaceutical and Health Care Management, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka
&
Yoshiharu KarubeLaboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
 show all
Pages 630-634 | Received 19 Dec 2011, Accepted 22 Dec 2011, Published online: 19 Feb 2012
 
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Abstract

We investigated the pharmacokinetics of gentamicin in a haemodialysis patient treated for endocarditis caused by methicillin-resistant Staphylococcus aureus and found that the administration of gentamicin immediately prior to dialysis was a suitable strategy for reaching target maximum drug concentration (Cmax) values and low trough levels.

Declaration of interest: Funding was provided by institutional sources only. None of the authors have any conflicts of interest to declare.

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