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Scandinavian Journal of Infectious Diseases Volume 46, 2014 - Issue 3
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Case Reports

Disseminated cryptococcosis, invasive aspergillosis, and mucormycosis in a patient treated with alemtuzumab for chronic lymphocytic leukaemia

Aurélia Henn From the Infectious and Tropical Diseases Department, Paris, FranceCorrespondence[email protected]
,
Guillaume Mellon From the Infectious and Tropical Diseases Department, Paris, France
,
Benoît Henry From the Infectious and Tropical Diseases Department, Paris, France
,
Damien Roos-WeilHematology Department, Groupe Hospitalier Universitaire Pitié Salpêtrière, Université Pierre et Marie Curie–Paris 6, Paris, France
,
Stéphane Jauréguiberry From the Infectious and Tropical Diseases Department, Paris, France
,
Pierre MordantThoracic Surgery Department, Hôpital Européen Georges Pompidou, Université René Descartes–Paris 5, Paris, France
,
Arnaud FekkarMycology and Parasitology Laboratory, Groupe Hospitalier Universitaire Pitié Salpêtrière, Université Pierre et Marie Curie–Paris 6, Paris, France
&
Eric Caumes From the Infectious and Tropical Diseases Department, Paris, France
 show all
Pages 231-234 | Received 26 Oct 2013, Accepted 29 Oct 2013, Published online: 23 Jan 2014
 
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Abstract

We report the case of a 42-y-old man treated with alemtuzumab for chronic lymphocytic leukaemia, who developed 3 successive deep fungal infections. Despite being treated with liposomal amphotericin B and 5-flucytosine for disseminated cryptococcosis, he developed pulmonary invasive aspergillosis, followed by pulmonary mucormycosis. Several deep fungal infections may occur in association in an immunocompromised host after treatment with alemtuzumab.

Declaration of interest: No funding; no conflict of interest.

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