Creatine Phosphokinase Relative to Acid Phosphatase, Lactate Dehydrogenase, Zinc and Fructose in Human Semen with Special Reference to Chronic Prostatitis

Abstract

The activities of the enzymes creatine phosphokinase (CPK), acid phosphatase (AcP), lactate dehydrogenase (LDH), and the amount of zinc and fructose was studied in ejaculates from 100 men, aged 24 to 43, and undergoing investigation because of infertility.

No significant correlation was found between the CPK activity of the semen and the number, motility or appearance of the spermatozoa. A significant correlation was found between the activity of CPK, on one band, and the activity of AcP and LDH and the amount of zinc on the other. A significant, negative correlation was demonstrated between the activity of CPK and the amount of fructose.

Sixty-five of the 100 men were investigated for chronic prostatitis. AcP and zinc levels were significantly lower in men with chronic prostatitis than in those without demonstrable inflammation, but this was not the case for CPK, LDH and fructose. No significant difference was found in the number of spermatozoa, their motility or appearance between men with chronic inflammatory process of the prostate and men without.

The male genital organs from 8 men who had died sudden deaths were examined regarding the activity of CPK, AcP, LDH and the amount of zinc. Enzyme activity and zinc were demonstrated in all the organs examined. The activity of CPK was highest in the vas deferens. The LDH activity was highest in the testis. The prostate differed clearly from the other organs by its high activity of AcP and large amount of zinc.